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In contrast, cyanocobalamin, a synthetic form of B12, must be converted into Methylcobalamin or adenosylcobalamin in the body before it can be used

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While efficacy endpoints for weight loss in those trials were modest, the compound exhibited a favorable safety profile, supporting its later GRAS designation for food use

However, headache incidence rates were similar between AOD-9604 and placebo groups, suggesting that many cases represented background occurrence rather than treatment-related effects