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(Beniuyt et al

As discussed later in this review, this mediator is the transcription factor peroxisome proliferator-activated receptor coactivator 1 (PGC-1 ), and its role in simultaneously inducing bioenergetic and antioxidant adaptations has been demonstrated in several experimental models of mtROS production, including treatments with paraquat and H 2 O 2

On the other hand, it may impact the redox potential of cells, which is also of signal importance, especially when one considers the results related to the reaction of CN with GSH (Gyamfi et al