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Each one carries a specific instruction, telling cells what to do and when to do it

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GLP-1 receptor agonists demonstrate proven efficacy with 1.8% HbA1c reduction and 6.1kg weight loss in clinical trials Approved peptide drugs show favourable safety profiles, but unregulated products pose contamination risks, with purity ranging from 1.7% to 100% Regulatory compliance varies significantly: the FDA classifies peptides as drugs, whilst WADA prohibits many peptides in competitive sport

To provide different perspectives on the estimated treatment effect in weight management RCTs, we recommend that future publications investigating new or already-approved weight-loss medications report the treatment policy estimand and the trial product estimand