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Changes in biomarkers after exposure to oxidative inducers are typically used to assess a natural products antioxidant efficacy

However, the direct oxidation of Cys and, to a lesser extent, methionine residues with H 2 O 2 can give rise to reversible modifications, such as sulfenic acid or disulfides or as methionine sulfoxides, respectively, which can be reduced by cellular activities

1135 Nicotinamide riboside (NR), an NAD + precursor, has been demonstrated to protect mitochondrial function in peripheral blood mononuclear cells and reduce inflammation in advanced heart failure patients