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Thus, our comparative genomic analyses illustrate that the fundamental functions of antioxidants have resulted in gene conservation throughout the animal kingdom, paving the way for functional analyses on these enzyme families in diverse animal phyla

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Specifically, we detected higher expression of the ferritinophagy mediator NCOA4 (encoding nuclear receptor coactivator 4, which binds to ferritin and delivers it to the autophagy-lysosomal machinery) 63 , as well as MCOLN1 (encoding mucolipin transient receptor potential cation channel, also known as TRPML1), which transports iron from the lysosomes to the cytoplasm 67 and is required for lysosomal biogenesis 68 (Fig