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2017;8:e2970

5.4.2 Age-related considerations in immunosuppressive therapy Age-specific pharmacotherapy considerations primarily involve pharmacokinetic differences and adverse effect susceptibility (101)

Interestingly, IR-deficient chondrocytes had increased IGF-1R levels and were more responsive to IGF-1 consistent with the notion that IGF-1/IGF-1R may compensate, at least in part, for loss of IR signaling