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The placenta produces 11 hydroxysteroid dehydrogenase 2 (11HSD2), which converts active glucocorticoids from the mother into the inactive form, ensuring maternal glucocorticoids are prevented from reaching fetal circulation ( FIGURE 1 Postnatally there are fewer mechanisms to protect the animal from the effects of stress and excessive glucocorticoids

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Mitochondrial DNA(mtDNA) is vulnerable to oxidative stress, resulting in both qualitative and quantitative changes

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