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10.1016/j.biotechadv.2017.12.015 Biotechnol

In particular examples, the modified FXa polypeptides are FX polypeptides that contain a light chain having the sequence of amino acids 1-139 shown in ID n : 134 (ie, corresponding to amino acids 1-139 of any of the SEQ ID NOS: 136-265), or a light chain having an amino acid sequence that is at least 75%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91% , 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more sequence identity with amino acids 1-139 shown in any of SEQ ID NOS: 134

doi: 10.1007/s40120-024-00642-5 6

The first time damaged mitochondria were linked to PD was through post-mortem studies on individuals who developed the condition after injecting themselves with synthetic heroin contaminated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)