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61 The primary targets of the released zinc are NMDARs containing GluN2A, which are responsive to nanomolar levels of extracellular zinc, thereby inhibiting receptor function

While these types of studies have been shown to be very useful for understanding the pathways involved in acute excitotoxicity, it has proven much more difficult to study chronic excitotoxicity in culture partly because it is not entirely clear how to define chronic in the context of cell culture