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When your gut releases GLP-1 after a meal to signal satiety to your brain, that is a peptide doing its job

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In the DRIVE-SHIFT clinical trial of virologically suppressed adults who switched to once-daily DOR/3TC/TDF, slight weight gain consistent with the weight gain expected in people without HIV was observed although approximately 40% of individuals lost weight or had no change in weight through 144 weeks [20]