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EVs, as messengers, are extensively involved in various physiological and pathological processes, including the cooperation and communication between the primary tumor sites and the secondary metastatic sites [125, 126]

& Ikeda, Y

Despite this, targeted therapies against the TGF pathway have yet to demonstrate satisfactory response rates or survival benefits in clinical trials, and no such therapies have been approved for cancer treatment 6,7

Without either of these processes functioning smoothly, free radicals cause detrimental damage to cells, our bodies do not detoxify and naturally, the onset of chronic disease begins