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Front Med (Lausanne) (2022) 9:874916

Sleep disturbances tied to semaglutide are typically dose-dependent and often improve as your body adjusts

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For instance, amitriptyline, imipramine, and desipramine strongly inhibit 5-HT reuptake, 344 clomipramine specifically inhibits NE reuptake, and nortriptyline can inhibit both NE and 5-HT reuptake while also exerting central anticholinergic effects