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Conditions such as systemic lupus erythematosus (SLE) are not included, despite their potential to cause pre-senile dementia through mechanisms like autoimmune antibodies targeting sodium channels on glutamatergic neurons [495]

PMID: 35894795

J Dermatol Treat 29:812814 Boozalis E, Khanna R, Zampella JG, Kwatra SG (2021) Tricyclic antidepressants for the treatment of chronic pruritus

Parallel animal models in the same study revealed that glutathione supplementation increased mitochondrial DNA by 53% and improved intermuscular pH, effectively preventing the acidic environment that leads to rapid muscle burning and exhaustion