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Hepatogastroenterology 2003;50:22258

Hyperpigmentation: Without strict sun protection, some patients may develop dark patches or uneven skin tone

Further, in such an approach, the penetration enhancer is not required, as is sometimes the case with transdermal, nasal, or mucosal oral routes of administration

Although vitamin C is absorbed from the gut via a sodium-dependent vitamin C transporter, most cells transport vitamin C in an oxidized form (dehydroascorbic acid) via glucose transporter 1