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Therefore, raising cellular NAD + through vitamin B3 family precursors or via drug-based interventions has become a broadly used strategy to restore mitochondrial and organismal homeostasis, with NAD + precursors becoming a popular supplementation approach

However, understanding potential risks enables informed decision-making

An underlying peripheral polyneuropathy has also been proposed as a co-factor in persistent pain

Iijima M, Okuma Y, Suzuki K, Yoshii F, Nogawa S, Osada T, Hirata K, Kitagawa K, Hattori N (2021) Associations between probable REM sleep behavior disorder, olfactory disturbance, and clinical symptoms in Parkinsons disease: a multicenter cross-sectional study