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Since the NLRP3s rigid crystal structure was used for molecular-docking simulations, interaction between the target receptor and 4-MESC was examined using molecular modeling, and dynamic behavior of the receptor and ligand was used to test the stability of bound conformation using dynamic simulation following compound chemistry in the pocket of NLRP3 PYD

Since prolonged exposure to CPAs can be toxic to cells, careful management of concentration and exposure time are critical

Based on the discussed results, antioxidants such as vitamins E and C, lipoic acid, and selenium have hypoglycemic effects, however, supplementation of patients with these vitamins did not bring the desired effect

Disease-modifying therapies for osteoarthritis