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Multiple factors contribute to its development, including lifestyle, exercise habits, comorbidities, and hormonal dysregulation ( The European Working Group on Sarcopenia in Older People (EWGSOP2) recently updated the diagnostic criteria for sarcopenia, emphasizing low muscle strength as a primary indicator, along with decreased muscle quantity or quality, and impaired physical performance ( 2.4 Adipose tissue and lipid metabolism The effects of HGH and IGF-1 on lipid metabolism are due to a complex interaction with other hormones controlling substrate metabolism