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Another study demonstrated that the combination of CAR-T cells and modified OVs expressing TNF- and IL-2 has a robust anti-tumor effect in the pancreatic ductal adenocarcinoma (PDA) murine model [48]

Laboratory investigations have explored its interactions with hypothalamic and limbic receptor systems, as well as its potential modulatory effects on stress hormone pathways in preclinical settings

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the conjugates render the activity of these conjugates selective, in general, for colon tissue, breast tissue and central nervous system tissue (targeted tissues)