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This information enables us to elucidate the effects of individual mutations and provide us with the genotype-phenotype correlation ( + binding site may cause more detrimental effects compared to mutations of residues in other less conserved sites

Results Influence of A pathology on ferroptosis-related protein levels To investigate the link between A pathology and ferroptosis-related proteins in post-mortem AD brain tissue, we selected mature A plaques in patients from several AD groups (termed AD1, AD2 and AD3 based on the pathology status, as described in Material and Methods section) and compared the expression of ferroptosis-related proteins in the A plaque area with the adjacent area without any plaques (Fig

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