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Whereas deficiencies in the enzymes (through genetic manipulation or use of inhibitors) exacerbate ischemia-reperfusion (I/R) injury, overexpression of these enzymes or treatment with pharmacological donors or inhaled gas therapy have been shown to have cytoprotective effects

In particular, mitochondrial calcium uptake occurs via the mitochondrial calcium uniporter (MCU), a calcium-sensitive channel that, when opened by elevated cytosolic calcium, allows calcium to flow into the matrix down the mitochondrions steep electrochemical gradient [56, 57]

Under resting conditions, ASC is S-glutathionylated (notably at Cys171), a modification that impairs ASC oligomerization and prevents spontaneous inflammasome formation 67

Its dosage guidelines should be as per the doctor's advice