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However, this delicate balance can be perturbed by an imbalance in the quantity of one or multiple components, potentially leading to dysfunction of the thyroid gland and a heightened susceptibility to autoimmune thyroid disorders ( The causal relationship between micronutrients and thyroid disease is not yet clear, but the potential application of micronutrients in the correction of GD disease is gaining attention

Postmortem studies indicate that KYN metabolism might also be modified in AD as increased concentrations of KYNA were found in the basal ganglia of AD patients (Baran et al., 2011), indicating that an upregulation of KYNA might be an endogenous protective response

Dimethylaminomicheliolide is a novel chemotherapeutic agent that induces apoptosis and autophagy by adjusting the ROS/MAPK signaling pathway and inhibiting the Akt/mTOR signaling pathway to treat gliomas (Wang et al., 2019)