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Clinical research on DIM typically uses doses between 100mg and 300mg per day , though the form of DIM matters.30 Standard (crystalline) DIM: Often used at higher doses (e.g., 200300mg) due to lower bioavailability BioResponse DIM (BR-DIM): A more bioavailable form used in many studies, often at doses around 100200mg per day, which may achieve similar effects to higher doses of standard DIM5 That said, higher doses dont necessarily lead to better results

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276 Interestingly, accumulation of the BNIP3 paralog BNIP3L/NIX protein not only triggers mitophagy but also activates the mTORC1 pathway