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Cox proportional and competing risk models were used to examine associations between PNPLA3 G allele and all-cause mortality (death of any cause) or composite liver (liver-specific deaths or new-onset varices, hepatic decompensation, HCC, or liver transplant)-, cardiovascular (cardiovascular or cerebrovascular-specific events or deaths)-, non-HCC malignancies (cancers-specific events, and mortality, excluding HCC)-, and chronic kidney disease (CKD) (new onset glomerular filtration rate 60 years or with T2DM ( p values for interactions 0.05)

doi: 10.1038/ajg.2014.202 174 ZhaoQYangWRWangXHLiGQXuLQCuiXet al

Finally, using ABA, the concentration of 1.0 mg L 1 resulted in the highest maturation frequency among all treatments evaluated ( p 0.05) (Table 4, Fig