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Disregarding the RT-PCR results, the frequent distinctive architecture observed in the NONO-TFE3 renal cell carcinomas along with the positive TFE3 staining and the equivocal TFE3 FISH results allowed for the subtyping of Xp11 translocation renal cell carcinomas

Two preclinical studies showed benefits of ascorbate in a familial ALS mouse model, and there are two case reports indicated that ascorbate was associated with improvement of the disease