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Furthermore, single-nucleotide polymorphisms XBP1 in patients with vitiligo illuminate the importance of this pathway in the pathogenesis of vitiligo ( 5 Nrf2 Antioxidant response pathway Oxidative stress is considered as a major event in vitiligo pathogenesis (Figure 2A)

2 Pharmacological Effects of Berberine 2.1 Oxidative Stress The effect of berberine on a variety of neurodegenerative diseases indicates that it may have a regulatory effect on the common pathways of these diseases