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Additionally, drugs like metformin and simvastatin, which can penetrate the blood-brain barrier and alter metabolic pathways, have shown great feasibility in the treatment of gliomas

Proc Natl Acad Sci USA 95:1171511720 Chang CH, Mayer M, Rivera-Ingraham G, Blondeau-Bidet E, Wu WY, Lorin-Nebel C, Lee TH (2021) Effects of temperature and salinity on antioxidant responses in livers of temperate ( Dicentrarchus labrax ) and tropical ( Chanos Chanos ) marine euryhaline fish