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Further translational research is needed to determine to which degree peripheral markers reflect central mechanisms in order to establish clinically useful peripheral biomarkers

As this complexity continues to unfold, one concept is rapidly gaining traction across disciplinesthat metabolism is not simply the backdrop to development, but a central signaling language through which neurobiological identity is formed and altered

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[58] Digoxin, HSP90 inhibitor 17-DMAG (alvespimycin), and navitoclax, among other senolytic agents, have been shown to significantly decrease atherosclerotic lesion formation and plaque burden in ApoE -/- mice of atherosclerosis