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Free Radic Biol Med 41:16941703 Boyd-Kimball D, Sultana R, Abdul HM, Butterfield DA (2005) Gamma-glutamylcysteine ethyl ester-induced up-regulation of glutathione protects neurons against Abeta(1-42)-mediated oxidative stress and neurotoxicity: implica-tions for Alzheimers disease

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Genetic redundancy within the pathway Given the genetic complexity of the pathway (Table 1), gene-specific Arabidopsis mutants have been very useful in defining the importance of the different isoforms