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Description

Many previous basic studies support that oxidative stress plays a role in oxaliplatin-related peripheral neuropathy 15,16,17

However, ellagic acid also has direct anti-androgenic effects by restricting 5-reductase, decreasing circulating testosterone levels

Thus, we hypothesized that individual cell states depend on highly specialized metabolic programs at the mitochondrial level which could reveal novel state-specific druggable vulnerabilities