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3 Multiple sclerosis: a major neuro-immunological disorder MS is the most prevalent chronic inflammatory, demyelinating, and neurodegenerative disorder of the CNS in young adults of 2040 years and more prevalent in women than men [29]

Understanding the pathways and mechanisms through which NRF2 operates could pave the way for new strategies in promoting better health overall for our beloved animal companions

Notably, RY103 showed efficacy in blocking IDO1-GCN2mediated immunosuppression in glioma models, but failed to impact MDSCs, possibly due to limited infiltration of MDSCs into the glioma TME (54)

Lysosomes and ER communicate through membrane contact sites, facilitating lipid transfer