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Despite considerable progress in the field of psychopharmacology, traditional antidepressant therapies persistently exhibit significant shortcomings, such as delayed therapeutic onset, suboptimal rates of remission, elevated instances of partial response, and adverse side-effect profiles (2, 3)

Additionally, the catalyst could activate the TLR7/8 agonist prodrug pro-imiquimod (pro-IMQ), further amplifying immune stimulation ( Figure 10B )

For others, you may receive a topical numbing cream

These mice also exhibit pruning of spines and silencing of excitatory synaptic transmission in the nucleus accumbens (Guo et al., 2022)