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The metastatic ability of lung cancer can be predicted based on their genomic and transcriptome characteristics [40], and the immunological landscape of the TME is also involved in reshaping the developmental characteristics of the tumor during metastasis [41]

A positive RF test in RA patients classifies them as having seropositive RA, which is strongly associated with more aggressive joint disease, rapid radiographic progression, and a higher incidence of extraarticular manifestations like rheumatoid nodules (Shmerling & Greisen, 2025)