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found that catechol-based PEG-D4 hydrogels generate substantial H 2 O 2 during oxidative crosslinking, which increases network stiffness, causes localized cytotoxicity, elevates PRX2 expression in dermal and tendon fibroblasts, and in vivo promotes superoxide production, macrophage recruitment, and M2 polarization, identifying H 2 O 2 as a central mediator of both material properties and biological responses in mussel-inspired biomaterials (Meng et al., 2017)

Different reasons, which we are not able to elucidate so far, could explain that mismatch, inter alia, (i) a model discrepancy to resolve processes, (ii) the model resolution, (iii) the geographical distribution of the ice core locations, and (iv) the different methods for the SAT 18 O calibration