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2.2 Mitochondrial dysfunction and oxidative stress Mitochondrial complex I deficiency is consistently observed in PD, leading to impaired ATP synthesis and overproduction of reactive oxygen species (ROS) (Chang and Chen, 2020

8.4 Final perspective The convergence of evidence from molecular studies, epidemiological investigations, and intervention trials establishes environmental endocrine disruptors as significant threats to male reproductive health with implications extending far beyond individual exposure events

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