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After several washed in 0.1 M PB, the sections were treated with 20 g/mL proteinase K for 10 min, followed by 0.3% H 2 O 2 in methanol for 10 min and 0.1% Triton X-100 in 0.1% sodium citrate for 2 min on ice

More than 40 adverse effects have been associated with KD, with the most notable being gastrointestinal discomfort, hyperlipidemia, kidney stones, and osteoporosis (as illustrated in Fig

In addition, it was reported that GEFR promoted the activation of newly synthesised KRAS, and aurora kinase A (AURKA) avoided drug-induced tumour cells by interacting with KRAS (G12C) and the downstream protein c-RAF 177