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Labels such as psychogenic or psychosomatic are applied by doctors, in part, because of a statistical correlation with higher levels of depression and anxiety.[ref] However, the physiological and cellular changes in people with chemical sensitivities are measurable, statistically significant, and visible, strongly suggesting a physiological cause rather than a psychological cause.[ref][ref] On the other hand, there are several clinical trials using specific solvents or chemical odors that found no statistical change in measured parameters (e.g

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This browning is mediated through multiple pathways including SIRT1/PGC-1 activation, increased expression of thermogenic genes (UCP1, PRDM16, PPAR), and enhanced mitochondrial biogenesis