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By enabling direct drug transport from the nasal cavity to the central nervous system, this approach effectively bypasses the bloodbrain barrier and minimizes systemic adverse effects, addressing critical limitations of current pharmacotherapies

Cell 17 (1), 4961

Model building and refinement The model building for the non-active class was initiated by individually fitting rigid-body components of the LBD extracted from the BPAM344-, and ConA-bound GluK2 structure (PDB code 9B36), and the TMD and ATD from the BPAM344 bound GluK2 structure (PDB code 8FWQ) into the cryo-EM map using Chimera