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Vitamin E also acts as an antioxidant that protects reproductive cells from damage caused by free radicals

Disclosures: Tassos Grammatikopoulos: Nothing to Disclose, Reha Artan: Nothing to Disclose, Pier Luigi Calvo: Nothing to Disclose, Piotr Czubkowski: IPSEN: Consultant, Buket Dalgic: Nothing to Disclose, Lorenzo D'Antiga: Selecta: Advisor, Vivet: Advisor, Spark: Advisor, Genespire: Advisor, Tome: Advisor, Mirum: Advisor, Ipsen/Albireo: Advisor, Intercept/Advanz Pharma: Advisor, Alexion/Astra Zeneca: Advisor, Ozlem Durmaz: Nothing to Disclose, Emmanuel Gonzales: Nothing to Disclose, Girish Gupte: Albireo: Grant/Research Support, Winita Hardikar: Ipsen: Advisor, Binita Kamath: Mirum: Consultant, Mirum: Grant/Research Support, Albireo/Ipsen: Consultant, Albireo/Ipsen: Grant/Research Support, Audentes: Consultant, Florence Lacaille: Nothing to Disclose, Cara Mack: Nothing to Disclose, Patrick McKiernan: Nothing to Disclose, Hasan zen: Nothing to Disclose, Sanjay Rajwal: Nothing to Disclose, Mathias Ruiz: Nothing to Disclose, Mohammad Shagrani: Nothing to Disclose, Eyal Shteyer: Nothing to Disclose, Nisreen Soufi: Mirum Pharmaceuticals: Advisor, Mary Elizabeth Tessier: Albireo/Ipsen: site PI for a pharmaceutical study, Albireo: site PI for a pharmaceutical study, Wendy Van Der Woerd: Mirum pharma: Consultant, Fatine Elaraki: Nothing to Disclose, Tao Gu: Nothing to Disclose, Michelle Hammerschmidt: Nothing to Disclose, Alejandra Ramirez-Santiago: Nothing to Disclose, Terese Wallefors: Nothing to Disclose, Douglas Silveira: Nothing to Disclose, Henkjan Verkade: Mirum: Grant/Research Support, Mirum: Consultant, Mirum: Speaking and Teaching, Ipsen / Albireo: Consultant, Ipsen / Albireo: Grant/Research Support, Ipsen / Albireo: Speaking and Teaching, Intercept: Consultant, Orphalan: Consultant 2349 AN INTERNATIONAL STUDY OF CIRCULATING FIBROSIS AND INFLAMMATORY MARKERS IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS Maryam Yazdanfar 1 Richard Dean 2 Joseph Zepeda 2 Sandeep Dhaliwal 2 Chung Heng Liu 2 Christina Ebert 3 Yi Luo 3 Lei Zhao 3 Palak Trivedi 4 Christopher Bowlus 5 , 1 University of California Davis School of Medicine, 2 University of California Davis, 3 Bristol-Myers Squibb, 4 University of Birmingham, 5 University of California, Davis Background: Primary sclerosing cholangitis (PSC) is a chronic cholestatic disease with a variable progression to cirrhosis, cholangiocarcinoma, and hepatic decompensation

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Other possibilities are also plausible, as for instance, IGF-I may influence the peripheral immune reaction, what in turn could reduce CNS inflammation, demyelination, and BBB permeability[82]