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The challenge with many interventions is that they lack selectivity, affecting multiple physiological systems simultaneously and creating side effects that limit their practical application or raise safety concerns

T., Zmachinski, C

Because of its availability for clinical application, rhGH became and is now the drug of choice, not only because of its efficacy but also because it avoids the risk of transmitting fatal, slow viral (prion-mediated) Creuzfeldt Jacob Disease which was sometimes associated with the cadaver-derived hormone

Mutation of E 74 to glutamine (Q) also induced helical formation in the CHAC2 loop 2, suggesting it might be the catalytically relevant glutamate residue that alternates with E 83 (Nguyen et al., 2020)