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Busulfan metabolism was modeled as a GSH-dependent conjugation process, with the scaling parameter S GSH quantifying the proportionality between busulfan metabolism and corresponding GSH depletion (Equation 2).Where represents the amount of busulfan in the central compartment, represents the amount of GSH in the theoretical compartment, represents the central volume of distribution, and represents the busulfan elimination constant

doi: 10.1016/j.bcp.2025.116797 [DOI] [PubMed] [Google Scholar] 171.Santn-Mrquez R, Alarcn-Aguilar A, Lpez-Diazguerrero NE, Chondrogianni N, Knigsberg M

A preprint version of this work has been deposited in the public depository ChemRxiv platform Source data are provided with this paper