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& Herceg, Z

doi: 10.1126/scitranslmed.3009759 21 BravoJ

Affected pigs may exhibit mottled erythematous eruptions of the skin, particularly around the snout, behind the ears, along the midline of the back, in the groin area, and over the abdomen [101]

Hydrocodone bitartrate and acetaminophen tablet-treated patients with significant chronic obstructive pulmonary disease or cor pulmonale, and those with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or pre-existing respiratory depression are at increased risk of decreased respiratory drive including apnea, even at recommended dosages of hydrocodone bitartrate and acetaminophen tablets [see WARNINGS, Life-Threatening Respiratory Depression]