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Another study showed that the number of autophagosomes in the liver of obese mice was increased, the fusion of autophagosomes and lysosomes was normal, and autophagy defects were caused by a decrease in cathepsin L and lysosomal acidification defects, which prevented the substrate degradation of autophagic lysosomes [14]

It has been discovered that sEV could serve as a carrier for a diverse array of substances, including proteins, lipids, and messenger RNA (mRNA), non-coding RNA (ncRNA), such as microRNA (miRNA) [6,7,8,9]