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While the bone marrow and hematopoietic cells are most affected, other organs involved in hematopoiesis, such as the thymus and spleen, also sustain injury due to IR [64, 65]

The findings suggest that the preservation of gut barrier integrity and regulation of gut microbiota and associated metabolites should not be overlooked in the treatment of kidney disease

The N-terminal residues of the A chain are conserved among vertebrate insulins and have been extensively investigated for their relevance in ligand receptor interactions