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The required frequency of injections ranges between daily and weekly [2]

Similarly, Cas13-mediated RNA editing experiments for mitochondrial diseases are exhibiting prolonged RNA knockdown without observable off-target consequences, offering clinical validation for transitory, programmable non-coding RNA modification in human tissues

Although the role of bombesins in modulating mucus secretion or muc5AC/muc5B regulation in COPD is unknown, given that bombesins are increased in COPD [193] and muc5B is also increased [188], then it is possible that either a direct or indirect relationship between bombesin signaling and muc5B expression exists