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It may also contribute to subtle detrimental effects on cognitive function 38 and may have a wide array of other psychiatric manifestations, such as propensity to gamble

Until that time when such heroic, hightech medicine has become effective, safe, and financially affordable, the available clinical experience suggests that PD management can be markedly improved by following an integrative medical model

To date, three key experimental strategies are used to manipulate or remove senescent cells: depleting senescent cells, manipulating triggering pathways of senescence (mainly P16 INK4A and P21 CIP1 ), and targeting senescent cells and/or their secreted factors pharmacologically [7]

Metformin: current knowledge