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Nose-to-brain delivery of self-assembled curcumin-lactoferrin nanoparticles: characterization, neuroprotective effect and in vivo pharmacokinetic study

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Based on survey responses from a convenience sample of 69 medical professionals (including physicians, nurses, advanced practitioners, medics, etc.), the smallest clinically meaningful reduction in hangover symptoms that would represent effective treatment using NAC was 69.4% (from a maximum score of 52 to 15.9), requiring a minimum sample size of only 4