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(iv) optimal Se status (100 nm/l in cell culture) is critical for alternative macrophage activation, leading to attenuated expression of proinflammatory mediators (Reference Nelson, Lei and Prabhu57)

Unlike the self-polymerization approach, requiring high alkalinity and long reaction times, the enzymatic method achieves fast polymerization under mild conditions, which broadens its range of substrates and applications (Magalhes et al., 2022)

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