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This suggests that while IL-4 can activate 12/15-LOX, the IL-4 concentrations in the lungs of asthma patients may not be sufficiently high to induce significant ALOX15 expression

According to previous investigations, APO ameliorated lung damage by reducing lipid peroxidation, inhibiting NOX expression and activity, blocking the NF-B pathway, and suppressing the transcription of pro-inflammatory cytokines in lung tissue (Kim et al

It can spread to your lower back and legs