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doi:10.1056/NEJMoa2104983

For instance, ACSL4 promotes the incorporation of PUFAs into phospholipids, making them vulnerable to lipoxygenase (ALOX)-mediated oxidation, which compromises the lipid bilayer and induces ferroptosis [17, 18]

The peptides interaction with IGF-binding proteins is diminished by its altered structure, which includes a longer chain and changed binding characteristics

NAD + is also produced through salvage pathways from nicotinamide and nicotinamide riboside precursors, however, people with deficiency or low activity of the GS gene exhibit severe secondary NAD + deficiency (Reference Hu, Ibrahim and Stucki15) , indicating that the glutamine supply is indispensable for NAD + synthesis (Reference Wojcik, Seidle and Bieganowski16)