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4423-A IDENTIFICATION OF microRNAs INVOLVED IN RESISTANCE OF LENVATINIB UNDER HYPOXIA IN HEPATOCELLULAR CARCINOMA Mari Satoh 1,2 , Takayuki Kogure 2 , Takehito Ito 3 , Masanori Takahashi 2 , Kensuke Usui 2 , Kouji Okada 2 and Kennichi Satoh 2 , (1)Tome City Toyosato Hospital, (2)Tohoku Medical and Pharmaceutical University, (3)Tohoku Medical and Pharmaceutical University Wakabayashi Hospital Background: Among the multi-kinase inhibitors for the treatment of hepatocellular carcinoma (HCC), lenvatinib has shown a superior response rate

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This age-related incomplete vesicular mobilization could be targeted for pharmacological interventions to promote autophagic and endosomal pathways [49]